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In these patients, the recommended dose is 5mg taken once a day at approximately the same time of day. The dose may be decreased to 2.5mg once a day based on individual tolerability. levitra manufacturer p<.001 p<.001What should I know about storage and disposal of this medication?Dígale a su médico acerca de todas las medicinas que usted esté usando, comience a usar, o deje de usar durante su tratamiento con vardenafil, especialmente:Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme. These drugs also inhibit other PDE enzymes. Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil.[7] Some sildenafil users see a bluish tinge and have a heightened sensitivity to light because of PDE6 inhibition.[8] Sildenafil and vardenafil also inhibit PDE1 more than tadalafil.[7] PDE1 is found in the brain, heart, and vascular smooth muscle.[7] It is thought that the inhibition of PDE1 by sildenafil and vardenafil leads to vasodilation, flushing, and tachycardia.[7] Tadalafil inhibits PDE11 more than sildenafil or vardenafil.[7] PDE11 is expressed in skeletal muscle, the prostate, the liver, the kidney, the pituitary gland, and the testes.[7] The effects on the body of inhibiting PDE11 are not known.[7]

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viagra 50mg Not all side effects for Cialis may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Dosing ConsiderationsA CYP3A4 inducer, rifampicin, reduced tadalafil AUC by 88%, relative to the AUC values for tadalafil alone (10 mg). This reduced exposure can be anticipated to decrease the efficacy of tadalafil; the magnitude of decreased efficacy is unknown. Other inducers of CYP3A4, such as phenobarbital, phenytoin, and carbamazepine, may also decrease plasma concentrations of tadalafil.

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